The Effect of Injection of Steroid and 5-Fluorouracil on Hypertrophic Scars of Rabbit
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons
;
: 210-217, 2011.
Article
in Korean
| WPRIM
| ID: wpr-785075
ABSTRACT
PURPOSE: This study was to evaluate the synergistic effects of combined therapy of steroid and anti-neoplastic drug injection on hypertrophic scars in a rabbit model.METHODS:
Adult male white rabbits weighing about 2.5 kg were used. After full thickness wounding (about 6 mm) over the ventral surface of each ear sized was made, either saline (control group), triamcinolone, 5-fluoruracil, and mixture of triamcinolone and 5-fluoruracil were injected once 16 days after the wound was made. Rabbits were sacrificed 2, 4 and 8 weeks after injection, and tissue specimens were prepared for histologic and histomorphometric examinations.RESULTS:
With the combined injection of triamcinolone and 5-fluoruracil, collagen fiber thickness was arranged in a somewhat irregular manner 2 weeks after injection. After 4 weeks, blood vessels and inflammatory cells were decreased, and collagen fibers were arranged in an almost parallel manner. By 8 weeks, almost same amount of connective tissue compared with adjacent normal tissue was observed.CONCLUSION:
These results indicated that combined injection of triamcinolone and 5-fluoruracil reduced the amount of hypertrophic scars by inhibition of fibroblasts and inflammatory cells. Therefore, combined injection of triamcinolone and 5-fluoruracil is a more potent and effective treatment of hypertrophic scars compared with the single injection of either triamcinolone or 5-fluorouracil.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood Vessels
/
Triamcinolone
/
Collagen
/
Cicatrix, Hypertrophic
/
Connective Tissue
/
Ear
/
Fibroblasts
/
Fluorouracil
Limits:
Adult
/
Animals
/
Humans
/
Male
Language:
Korean
Journal:
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons
Year:
2011
Type:
Article
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