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The Effect of Low-intensity Pulsed Ultrasound on Osteogenesis in Mini-pig Mandibles
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons ; : 467-477, 2011.
Article in Korean | WPRIM | ID: wpr-785116
ABSTRACT
PURPOSE: The objective of this study was to examine the affected period and the amount of bone formation during osteogenesis of intramembranous bone using low-intensity pulsed ultrasound (LPUS) in vivo.

METHODS:

Xeno-bone (Bio-oss) and autogenous bone were grafted bilaterally into mini-pig mandibles. The left mandible served as the control and the other mandible was treated with 3 MHz, 160 mW (output, 0.8 mW) ultrasound stimulation for 7 days 15 minutes per day. The mini-pigs were sacrificed at 1, 2, 4, and 8 weeks, and micro computed tomography (microCT), a microscopic examination, and a statistical analysis were performed on the specimens.

RESULTS:

Based on a computerized image analysis of the microCT scans, the experimental group had an average 150% more new bone formation than that in the control group. The effect of LPUS continued during the post operative 2 weeks. The histomorphological microscopic examination showed similar results.

CONCLUSION:

Our results suggest the LPUS had an effect on early intramembranous bone formation in vivo.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Osteogenesis / Transplants / X-Ray Microtomography / Mandible Language: Korean Journal: Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Osteogenesis / Transplants / X-Ray Microtomography / Mandible Language: Korean Journal: Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons Year: 2011 Type: Article