Distribution of TT Virus Genotypes and Genogroups in 69 Healthy and 59 Hepatitis B Virus Infected Korean Individuals / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
;
: 257-264, 2007.
Article
in Korean
| WPRIM
| ID: wpr-7855
ABSTRACT
BACKGROUND:
TT virus (TTV) infection is highly prevalent in general population and patients with hepatitis B virus (HBV) infection. The aim of the present study was to determine the distribution of the genotypes and genogroups of TTV in healthy and HBV-infected individuals in Korea.METHODS:
Distribution of TTV genotypes and genogroups was investigated in the serum samples of 69 healthy and 59 HBV-infected individuals. PCR products of N22 region were genotyped by sequence analysis. TTV genogroups were determined by 5 different genogroup-specific PCR assays.RESULTS:
Among the 20 sequenced isolates, 9 (45%) were genotype 2, 8 (40%) were genotype 1, 2 (10%) were genotype 3, and 1 (5%) was genotype 4. TTV genogroup 4 was found most frequently (52/128), followed by genogroup 3 (42/128), genogroup 1 (35/128), genogroup 5 (32/128), and genogroup 2 (1/128). Mixed infections with different genogroups were frequent.CONCLUSIONS:
TTV genotype 2 and 1 are predominant genotypes. TTV genotype 3 was detected for the first time in Korea. TTV genogroups 4 and 3 were predominant genogroups. No significant difference was observed in the distribution of TTV genogroups between healthy and HBV-infected individuals.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phylogeny
/
Molecular Sequence Data
/
Polymerase Chain Reaction
/
Amino Acid Sequence
/
Torque teno virus
/
DNA Virus Infections
/
Genotype
/
Hepatitis B
/
Korea
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Korean
Journal:
The Korean Journal of Laboratory Medicine
Year:
2007
Type:
Article
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