Pathology of C3 Glomerulopathy
Childhood Kidney Diseases
;
: 93-99, 2019.
Article
in English
| WPRIM
| ID: wpr-785578
ABSTRACT
C3 glomerulopathy is a renal disorder involving dysregulation of alternative pathway complement activation. In most instances, a membranoproliferative pattern of glomerular injury with a prevalence of C3 deposition is observed by immunofluorescence microscopy. Dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) are subclasses of C3 glomerulopathy that are distinguishable by electron microscopy. Highly electron-dense transformation of glomerular basement membrane is characteristic of DDD. C3GN should be differentiated from post-infectious glomerulonephritis and other immune complex-mediated glomerulonephritides showing C3 deposits.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Microscopy, Electron
/
Glomerulonephritis, Membranoproliferative
/
Prevalence
/
Complement Activation
/
Complement Pathway, Alternative
/
Dichlorodiphenyldichloroethane
/
Glomerular Basement Membrane
/
Glomerulonephritis
/
Microscopy, Fluorescence
Type of study:
Prevalence study
Language:
English
Journal:
Childhood Kidney Diseases
Year:
2019
Type:
Article
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