Genetic Basis of Steroid Resistant Nephrotic Syndrome
Childhood Kidney Diseases
;
: 86-92, 2019.
Article
in English
| WPRIM
| ID: wpr-785579
ABSTRACT
Steroid-resistant nephrotic syndrome (SRNS) has long been a challenge for clinicians due to its poor responsiveness to immunosuppressants, and rapid progression to end-stage renal disease. Identifying a monogenic cause for SRNS may lead to a better understanding of podocyte structure and function in the glomerular filtration barrier. This review focuses on genes associated with slit diaphragm, actin cytoskeleton, transcription factors, nucleus, glomerular basement membrane, mitochondria, and other proteins that affect podocyte biology.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Proteinuria
/
Transcription Factors
/
Biology
/
Actin Cytoskeleton
/
Diaphragm
/
Glomerular Basement Membrane
/
Podocytes
/
Glomerular Filtration Barrier
/
Immunosuppressive Agents
/
Kidney Failure, Chronic
Type of study:
Prognostic study
Language:
English
Journal:
Childhood Kidney Diseases
Year:
2019
Type:
Article
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