Bilirubin and risk of ischemic heart disease in Korea: a two-sample Mendelian randomization study / 한국역학회지
Epidemiology and Health
; : 2019034-2019.
Article
in En
| WPRIM
| ID: wpr-785753
Responsible library:
WPRO
ABSTRACT
OBJECTIVES: Bilirubin is an endogenous antioxidant that protects cells against oxidative stress. Increased plasma levels of bilirubin have been associated with a reduced risk of ischemic heart disease (IHD) in previous studies. Nonetheless, whether those associations reflect a true protective effect of bilirubin on IHD, rather than confounding or reverse causation, remains unknown. Therefore, we applied two-sample Mendelian randomization to evaluate the causal association between bilirubin levels and IHD risk in a Korean population.METHODS: A total of 5 genetic variants—TRPM8 (rs10490012), USP40 (rs12993249), ATG16L1 (rs2119503), SLCO1B1 (rs4149014), and SLCO1B3 (rs73233620)—were selected as genetic instruments for serum bilirubin levels using a community-based cohort, the Korean Genome and Epidemiology Study, comprising 33,598 subjects. We then evaluated their impact on IHD using the Korean Cancer Prevention Study-II cohort.RESULTS: Among the 5 instrumental variables that showed significant associations with serum bilirubin levels, rs12993249 (USP40) showed the most significant association (p<2.36×10−105). However, we found no significant association between serum bilirubin levels and IHD. Sensitivity analyses demonstrated a consistent association, suggesting that our observations were robust.CONCLUSIONS: Using two-sample Mendelian randomization, we found no association between serum bilirubin levels and IHD. Further studies that confirm the observed interactions among other ethnicities are warranted.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Plasma
/
Bilirubin
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Random Allocation
/
Epidemiology
/
Cohort Studies
/
Genome
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Myocardial Ischemia
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Oxidative Stress
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Korea
Type of study:
Clinical_trials
/
Etiology_studies
/
Incidence_studies
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Observational_studies
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Risk_factors_studies
Country/Region as subject:
Asia
Language:
En
Journal:
Epidemiology and Health
Year:
2019
Type:
Article