B Cell Immunophenotyping and Transcriptional Profiles of Memory B Cells in Patients with Myasthenia Gravis
Experimental Neurobiology
;
: 720-726, 2019.
Article
in English
| WPRIM
| ID: wpr-785786
ABSTRACT
Myasthenia gravis (MG) is an autoimmune neuromuscular junction disorders mediated by various autoantibodies. Although most patients with MG require chronic immunosuppressive treatment to control disease activity, appropriate surveillance biomarkers that monitor disease activity or potential toxicity of immunosuppressants are yet to be developed. Herein, we investigated quantitative distribution of peripheral blood B cell subsets and transcriptional profiles of memory B cells (CD19+ CD27+) in several subgroups of MG patients classified according to the Myasthenia Gravis Foundation of America (MGFA) Clinical Classification. This study suggests potential immunologic B-cell markers that may guide treatment decision in future clinical settings.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autoantibodies
/
Americas
/
B-Lymphocytes
/
Biomarkers
/
Immunophenotyping
/
B-Lymphocyte Subsets
/
Classification
/
Neuromuscular Junction Diseases
/
Transcriptome
/
Flow Cytometry
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Experimental Neurobiology
Year:
2019
Type:
Article
Similar
MEDLINE
...
LILACS
LIS