Select Macrophage Noncoding RNAs of Interest in Cardiovascular Disease
Journal of Lipid and Atherosclerosis
;
: 153-161, 2020.
Article
in English
| WPRIM
| ID: wpr-786075
ABSTRACT
Cardiovascular disease remains a leading cause of morbidity and mortality worldwide. Aspects of disease severity that are associated with heightened inflammation, such as during atherosclerosis or after myocardial infarction, are correlated with macrophage activation and macrophage polarization of the transcriptome and secretome. In this setting, non-coding RNAs (ncRNAs) may be as abundant as protein-coding genes and are increasingly recognized as significant modulators of macrophage gene expression and cytokine secretion, although the functions of most ncRNAs—and in particular, long non-coding RNAs—remain unknown. Herein, we discuss a subset of specific ncRNAs of interest in macrophages in atherosclerosis and during myocardial inflammation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Cardiovascular Diseases
/
Gene Expression
/
Mortality
/
RNA, Untranslated
/
Atherosclerosis
/
Transcriptome
/
RNA, Long Noncoding
/
Inflammation
/
Macrophage Activation
/
Macrophages
Type of study:
Prognostic study
Language:
English
Journal:
Journal of Lipid and Atherosclerosis
Year:
2020
Type:
Article
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