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Select Macrophage Noncoding RNAs of Interest in Cardiovascular Disease
Journal of Lipid and Atherosclerosis ; : 153-161, 2020.
Article in English | WPRIM | ID: wpr-786075
ABSTRACT
Cardiovascular disease remains a leading cause of morbidity and mortality worldwide. Aspects of disease severity that are associated with heightened inflammation, such as during atherosclerosis or after myocardial infarction, are correlated with macrophage activation and macrophage polarization of the transcriptome and secretome. In this setting, non-coding RNAs (ncRNAs) may be as abundant as protein-coding genes and are increasingly recognized as significant modulators of macrophage gene expression and cytokine secretion, although the functions of most ncRNAs—and in particular, long non-coding RNAs—remain unknown. Herein, we discuss a subset of specific ncRNAs of interest in macrophages in atherosclerosis and during myocardial inflammation.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Cardiovascular Diseases / Gene Expression / Mortality / RNA, Untranslated / Atherosclerosis / Transcriptome / RNA, Long Noncoding / Inflammation / Macrophage Activation / Macrophages Type of study: Prognostic study Language: English Journal: Journal of Lipid and Atherosclerosis Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Cardiovascular Diseases / Gene Expression / Mortality / RNA, Untranslated / Atherosclerosis / Transcriptome / RNA, Long Noncoding / Inflammation / Macrophage Activation / Macrophages Type of study: Prognostic study Language: English Journal: Journal of Lipid and Atherosclerosis Year: 2020 Type: Article