Ceramides: Nutrient Signals that Drive Hepatosteatosis
Journal of Lipid and Atherosclerosis
;
: 50-65, 2020.
Article
in English
| WPRIM
| ID: wpr-786082
ABSTRACT
Ceramides are minor components of the hepatic lipidome that have major effects on liver function. These products of lipid and protein metabolism accumulate when the energy needs of the hepatocyte have been met and its storage capacity is full, such that free fatty acids start to couple to the sphingoid backbone rather than the glycerol moiety that is the scaffold for glycerolipids (e.g., triglycerides) or the carnitine moiety that shunts them into mitochondria. As ceramides accrue, they initiate actions that protect cells from acute increases in detergent-like fatty acids; for example, they alter cellular substrate preference from glucose to lipids and they enhance triglyceride storage. When prolonged, these ceramide actions cause insulin resistance and hepatic steatosis, 2 of the underlying drivers of cardiometabolic diseases. Herein the author discusses the mechanisms linking ceramides to the development of insulin resistance, hepatosteatosis and resultant cardiometabolic disorders.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Triglycerides
/
Insulin Resistance
/
Carnitine
/
Ceramides
/
Hepatocytes
/
Fatty Acids
/
Fatty Acids, Nonesterified
/
Fatty Liver
/
Non-alcoholic Fatty Liver Disease
/
Glucose
Language:
English
Journal:
Journal of Lipid and Atherosclerosis
Year:
2020
Type:
Article
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