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Comparison of Squamous Cell Carcinoma of the Tongue between Young and Old Patients
Article in English | WPRIM | ID: wpr-786128
Responsible library: WPRO
ABSTRACT

BACKGROUND:

The worldwide incidence of squamous cell carcinoma of the tongue (SCCOT) in young patients has been increasing. We investigated clinicopathologic features of this unique population and compared them with those of SCCOT in the elderly to delineate its pathogenesis.

METHODS:

We compared clinicopathological parameters between patients under and over 45 years old. Immunohistochemical assays of estrogen receptor, progesterone receptor, androgen receptor, p53, p16, mdm2, cyclin D1, and glutathione S-transferase P1 were also compared between them.

RESULTS:

Among 189 cases, 51 patients (27.0%) were under 45 years of age. A higher proportion of women was seen in the young group, but was not statistically significant. Smoking and drinking behaviors between age groups were similar. Histopathological and immunohistochemical analysis showed no significant difference by age and sex other than higher histologic grades observed in young patients.

CONCLUSIONS:

SCCOT in young adults has similar clinicopathological features to that in the elderly, suggesting that both progress via similar pathogenetic pathways.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Smoke / Tongue / Aged / Female / Humans / Mouth Neoplasms / Immunohistochemistry / Carcinoma, Squamous Cell / Smoking / Receptors, Androgen Type of study: Incidence study Language: English Journal: Journal of Pathology and Translational Medicine Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Smoke / Tongue / Aged / Female / Humans / Mouth Neoplasms / Immunohistochemistry / Carcinoma, Squamous Cell / Smoking / Receptors, Androgen Type of study: Incidence study Language: English Journal: Journal of Pathology and Translational Medicine Year: 2019 Type: Article