SYNTAX Score and SYNTAX Score II Can Predict the Clinical Outcomes of Patients with Left Main and/or 3-Vessel Disease Undergoing Percutaneous Coronary Intervention in the Contemporary Cobalt-Chromium Everolimus-Eluting Stent Era
Korean Circulation Journal
;
: 22-34, 2020.
Article
in English
| WPRIM
| ID: wpr-786215
ABSTRACT
BACKGROUND AND OBJECTIVES:
The impact of SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery score (SS) and SS II in patients who receive percutaneous coronary intervention with second-generation everolimus-eluting stents (EES) has not been fully validated.METHODS:
The SS, SS II were calculated in 1,248 patients with left main and/or 3-vessel disease treated with EES. Patient-oriented composite endpoint (POCE; all-cause death, any myocardial infarction (MI), any revascularization) and target lesion failure (TLF cardiac death, target-vessel MI, target lesion revascularization) were analyzed.RESULTS:
The mean SS was 21.1±9.6. Three-year POCE increased according to the SS group (15.2% vs. 19.9% vs. 27.4% for low (≤22), intermediate (≥23, ≤32), high (≥33) SS groups, p<0.001). By multivariate Cox proportional hazard analysis, SS group was an independent predictor of 3-year POCE (hazard ratio, 1.324; 95% confidence interval, 1.095–1.601; p=0.004). The receiver operating characteristic curves revealed that the SS II was superior to the SS for 3-year POCE prediction (area under the curve [AUC] 0.611 vs. 0.669 for SS vs. SS II, p=0.019), but not for 3-year TLF (AUC 0.631 vs. 0.660 for SS vs. SS II, p=0.996). In subgroup analysis, SS II was superior to SS in patients with cardiovascular clinical risk factors, and in those presenting as stable angina.CONCLUSIONS:
The usefulness of SS and SS II was still valid in patients with left main and/or 3-vessel disease. SS II was superior to SS for the prediction of patient-oriented outcomes, but not for lesion-oriented outcomes.TRIAL REGISTRATION ClinicalTrials.gov Identifier NCT00698607ClinicalTrials.gov Identifier NCT01605721
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thoracic Surgery
/
Stents
/
Risk Factors
/
ROC Curve
/
Taxus
/
Death
/
Drug-Eluting Stents
/
Angina, Stable
/
Percutaneous Coronary Intervention
/
Myocardial Infarction
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Korean Circulation Journal
Year:
2020
Type:
Article
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