Evolutionary Genetic Models of Mental Disorders
Journal of the Korean Society of Biological Psychiatry
;
: 33-38, 2019.
Article
in Korean
| WPRIM
| ID: wpr-786255
ABSTRACT
Psychiatric disorder as dysfunctional behavioural syndrome is a paradoxical phenomenon that is difficult to explain evolutionarily because moderate prevalence rate, high heritability and relatively low fitness are shown. Several evolutionary genetic models have been proposed to address this paradox. In this paper, I explain each model by dividing it into selective neutrality, mutation-selection balance, and balancing selection hypothesis, and discuss the advantages and disadvantages of them. In addition, the feasibility of niche specialization and frequency dependent selection as the plausible explanation about the central paradox is briefly discussed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prevalence
/
Mental Disorders
/
Models, Genetic
Type of study:
Diagnostic study
/
Prevalence study
Language:
Korean
Journal:
Journal of the Korean Society of Biological Psychiatry
Year:
2019
Type:
Article
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