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The Effect of Regular Exercise on Insulin Sensitivity in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Diabetes & Metabolism Journal ; : 253-271, 2016.
Article in English | WPRIM | ID: wpr-78629
ABSTRACT
The purpose of this study was to examine the effect of regular exercise training on insulin sensitivity in adults with type 2 diabetes mellitus (T2DM) using the pooled data available from randomised controlled trials. In addition, we sought to determine whether short-term periods of physical inactivity diminish the exercise-induced improvement in insulin sensitivity. Eligible trials included exercise interventions that involved ≥3 exercise sessions, and reported a dynamic measurement of insulin sensitivity. There was a significant pooled effect size (ES) for the effect of exercise on insulin sensitivity (ES, –0.588; 95% confidence interval [CI], –0.816 to –0.359; P<0.001). Of the 14 studies included for meta-analyses, nine studies reported the time of data collection from the last exercise bout. There was a significant improvement in insulin sensitivity in favour of exercise versus control between 48 and 72 hours after exercise (ES, –0.702; 95% CI, –1.392 to –0.012; P=0.046); and this persisted when insulin sensitivity was measured more than 72 hours after the last exercise session (ES, –0.890; 95% CI, –1.675 to –0.105; P=0.026). Regular exercise has a significant benefit on insulin sensitivity in adults with T2DM and this may persist beyond 72 hours after the last exercise session.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Insulin Resistance / Data Collection / Diabetes Mellitus, Type 2 / Resistance Training / Glucose Tolerance Test / Insulin Type of study: Controlled clinical trial / Diagnostic study / Systematic reviews Limits: Adult / Humans Language: English Journal: Diabetes & Metabolism Journal Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Insulin Resistance / Data Collection / Diabetes Mellitus, Type 2 / Resistance Training / Glucose Tolerance Test / Insulin Type of study: Controlled clinical trial / Diagnostic study / Systematic reviews Limits: Adult / Humans Language: English Journal: Diabetes & Metabolism Journal Year: 2016 Type: Article