Antitumor effect of TW-37, a BH3 mimetic in human oral cancer / 한국실험동물학회지
Laboratory Animal Research
;
: 194-201, 2019.
Article
in English
| WPRIM
| ID: wpr-786403
ABSTRACT
TW-37 is a small molecule B cell lymphoma-2 (Bcl-2) homology 3 mimetic with potential anticancer activities. However, the in vivo anti-cancer effect of TW-37 in human oral cancer has not been properly studied yet. Here, we attempted to confirm antitumor activity of TW37 in human oral cancer. TW-37 significantly inhibited cell proliferation and increased the number of dead cells in MC-3 and HSC-3 human oral cancer cell lines. TW-37 enhanced apoptosis of both cell lines evidenced by annexin V/propidium iodide double staining, sub-G1 population analysis and the detection of cleaved poly (ADP-ribose) polymerase and caspase-3. In addition, TW-37 markedly downregulated the expression of Bcl-2 protein, while not affecting Bcl-xL or myeloid cell leukemia-1. In vivo, TW-37 inhibited tumor growth in a nude mice xenograft model without any significant liver and kidney toxicities. Collectively, these data reveal that TW-37 may be a promising small molecule to inhibit human oral cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Mouth Neoplasms
/
Cell Line
/
Apoptosis
/
Myeloid Cells
/
Cell Proliferation
/
Caspase 3
/
Heterografts
/
Kidney
/
Liver
/
Mice, Nude
Limits:
Animals
/
Humans
Language:
English
Journal:
Laboratory Animal Research
Year:
2019
Type:
Article
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