Risk Factors for Delayed Hyperthyrotropinemia in Late Preterm Infants
Neonatal Medicine
;
: 204-212, 2019.
Article
in English
| WPRIM
| ID: wpr-786440
ABSTRACT
PURPOSE:
This study aimed to investigate the prevalence of delayed thyroid dysfunction based on iodine disinfectant use and to analyze associated risk factors.METHODS:
A retrospective study was conducted on late preterm infants admitted to the neonatal intensive care unit between January 2010 and June 2018, who underwent neonatal thyroid screening (NTS) and ≥2 thyroid function tests (TFTs). NTS was performed 3 days after birth, with at least two TFTs 1 week and 2 to 4 weeks after birth. To distinguish between normal and dysfunctional thyroid levels, we reviewed TFT results at 2 to 4 weeks and examined possible risk factors for the development of thyroid dysfunction.RESULTS:
Of 295 late preterm infants, 262 were enrolled with a mean gestational age and birth weight of 34.8±0.7 weeks and 2,170±454 g, respectively. A total of 7.6% developed hyperthyrotropinemia at the age of 24.3±14.6 days (range, 12 to 69). The incidence of hyperthyrotropinemia during iodine use was approximately 12.6%, while that during discontinuation was 2.4% (P=0.002). Multivariate analysis revealed that small for gestational age (SGA), iodine disinfectant use, and abnormal NTS results were significant risk factors for delayed hyperthyrotropinemia (adjusted odds ratio [AOR] 4.27, P=0.008; AOR 8.24, P=0.003; and AOR 7.80, P=0.002, respectively).CONCLUSION:
Delayed hyperthyrotropinemia was prevalent in late preterm infants exposed to topical iodine and those identified as being SGA. Secondary TFTs should be considered 2 to 4 weeks after birth for this population at risk.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thyroid Function Tests
/
Thyroid Gland
/
Population Characteristics
/
Birth Weight
/
Infant, Premature
/
Thyrotropin
/
Intensive Care, Neonatal
/
Odds Ratio
/
Mass Screening
/
Incidence
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
/
Screening study
Limits:
Humans
/
Infant, Newborn
Language:
English
Journal:
Neonatal Medicine
Year:
2019
Type:
Article
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