Gallbladder Paraganglioma Associated with SDHD Mutation: a Potential Pitfall on ¹⁸F-FDOPA PET Imaging / 핵의학분자영상
Nuclear Medicine and Molecular Imaging
;
: 144-147, 2019.
Article
in English
| WPRIM
| ID: wpr-786457
ABSTRACT
A 36-year-old male patient initially presented with hypertension, tinnitus, bilateral carotid masses, a right jugular foramen, and a periaortic arch mass with an elevated plasma dopamine level but an otherwise normal biochemical profile. On surveillance MRI 4 years after initial presentation, he was found to have a 2.2-cm T2 hyperintense lesion with arterial enhancement adjacent to the gallbladder, which demonstrated avidity on ⁶⁸Ga-DOTATATE PET/CTand retrospectively on ¹⁸F-FDOPA PET/CT but was nonavid on ¹⁸F-FDG PET/CT. Biochemical work-up including plasma catecholamines, metanephrines, and chromogranin A levels were found to be within normal limits. This lesion was surgically resected and was confirmed to be a paraganglioma (PGL) originating from the gallbladder wall on histopathology. Pheochromocytoma (PHEO) and PGL are rare tumors of the autonomic nervous system. Succinate dehydrogenase subunit D (SDHD) pathogenic variants of the succinate dehydrogenase complex are usually involved in parasympathetic, extra-adrenal, multifocal head, and neck PGLs. We report an unusual location of PGL in the gallbladder associated with SDHD mutation which could present as a potential pitfall on ¹⁸F-FDOPA PET/CT as its normal excretion occurs through biliary system and gallbladder. This case highlights the superiority of ⁶⁸Ga-DOTATATE in comparison to ¹⁸F-FDOPA and ¹⁸F-FDG in the detection of SDHD-related parasympathetic PGL.ClinicalTrials.gov Identifier NCT00004847.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paraganglioma
/
Pheochromocytoma
/
Plasma
/
Autonomic Nervous System
/
Succinate Dehydrogenase
/
Tinnitus
/
Biliary Tract
/
Magnetic Resonance Imaging
/
Catecholamines
/
Dopamine
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Nuclear Medicine and Molecular Imaging
Year:
2019
Type:
Article
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