Quantitative Imaging of Alpha-Emitting Therapeutic Radiopharmaceuticals / 대한핵의학회잡지
Korean Journal of Nuclear Medicine
;
: 182-188, 2019.
Article
in English
| WPRIM
| ID: wpr-786473
ABSTRACT
Targeted alpha therapy (TAT) is an active area of drug development as a highly specific and highly potent therapeutic modality that can be applied to many types of late-stage cancers. In order to properly evaluate its safety and efficacy, understanding biokinetics of alpha-emitting radiopharmaceuticals is essential. Quantitative imaging of alpha-emitting radiopharmaceuticals is often possible via imaging of gammas and positrons produced during complex decay chains of these radionuclides. Analysis of the complex decay chains for alpha-emitting radionuclides (Tb-149, At-211, Bi-212 (decayed from Pb-212), Bi-213, Ra-223, Ac- 225, and Th-227) with relevance to imageable signals is attempted in this mini-review article. Gamma camera imaging, single-photon emission computed tomography, positron emission tomography, bremsstrahlung radiation imaging, Cerenkov luminescence imaging, and Compton cameras are briefly discussed as modalities for imaging alpha-emitting radiopharmaceuticals.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Radioisotopes
/
Radionuclide Imaging
/
Tomography, Emission-Computed
/
Tomography, Emission-Computed, Single-Photon
/
Radiopharmaceuticals
/
Positron-Emission Tomography
/
Luminescence
/
Electrons
Language:
English
Journal:
Korean Journal of Nuclear Medicine
Year:
2019
Type:
Article
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