Orbital IgG4 Disease: Imaging Findings on 68Ga-DOTANOC PET/CT / 대한핵의학회잡지
Korean Journal of Nuclear Medicine
;
: 432-435, 2019.
Article
in English
| WPRIM
| ID: wpr-786497
ABSTRACT
Immunoglobulin G4 (IgG4)–related diseases are a spectrum of systemic inflammatory conditions of unknown etiology, which are characterized by infiltration of tissues by IgG4 plasma cells and sclerosing inflammation (Cheuk and Chan Adv Anat Pathol 17303-32, 2010). Although this condition was initially described in relation to autoimmune pancreatitis, now it has been reported in almost every organ system of body (Zen and Nakanuma Am J Surg Pathol 341812-9, 2010, Masaki et al. Ann Rheuma Dis 681310-5, 2009). Orbital involvement by IgG4 disease can involve extraocular muscles (EOM), lacrimal glands, conjunctiva, eyelids, infraorbital nerve, orbital fat, and nasolacrimal system (McNab and McKelvie. Ophthal Plast Reconstr Surg 31167-78, 2015, Katsura et al. Neuroradiology 54873-82, 2012). The basis of using ⁶⁸Ga-DOTANOC PET/CT in IgG4 orbital disease is the known expression of somatostatin receptors in chronic inflammatory cells (Cuccurullo et al. Indian J Radiol Imaging 27509-16, 2017) and also avidity shown previously in other IgG4-related diseases (Cheng et al. Clin Nucl Med 43773-6, 2018).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Orbit
/
Orbital Diseases
/
Pancreatitis
/
Plasma Cells
/
Immunoglobulin G
/
Immunoglobulins
/
Receptors, Somatostatin
/
Conjunctiva
/
Eyelids
/
Positron Emission Tomography Computed Tomography
Type of study:
Diagnostic study
Language:
English
Journal:
Korean Journal of Nuclear Medicine
Year:
2019
Type:
Article
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