Intensity-modulated radiotherapy for stage I glottic cancer: a short-term outcomes compared with three-dimensional conformal radiotherapy
Radiation Oncology Journal
;
: 271-278, 2019.
Article
| WPRIM
| ID: wpr-786562
ABSTRACT
PURPOSE:
To investigate the differences in treatment outcomes between two radiation techniques, intensity-modulated radiotherapy (IMRT) and three-dimensional conformal radiotherapy (3DCRT).MATERIALS ANDMETHODS:
We retrospectively analyzed 160 (IMRT = 23, 3DCRT = 137) patients with stage I glottic cancer treated from January 2005 through December 2016. The IMRT was performed with TomoTherapy (16 patients), volumetric-modulated arc therapy (6 patients), and step-and-shoot technique (1 patient), respectively. The 3DCRT was performed with bilateral parallel opposing fields. The median follow-up duration was 30 months (range, 31 to 42 months) in the IMRT group and 65 months (range, 20 to 143 months) in the 3DCRT group.RESULTS:
The 5-year overall survival and 3-year local control rates of the 160 patients were 95.7% and 91.4%, respectively. There was no significant difference in 3-year local control rates between the IMRT and 3DCRT groups (94.4% vs. 91.0%; p = 0.587). Thirteen of 137 patients in the 3DCRT group had recurrences. In the IMRT group, one patient had a recurrence at the true vocal cord. Patients treated with IMRT had less grade 2 skin reaction than the 3DCRT group, but this had no statistical significance (4.3% vs. 21.2%; p = 0.080).CONCLUSION:
IMRT had comparable outcomes with 3DCRT, and a trend of less acute skin reaction in stage I glottic cancer patients
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Skin
/
Vocal Cords
/
Laryngeal Neoplasms
/
Retrospective Studies
/
Follow-Up Studies
/
Radiotherapy, Conformal
/
Radiotherapy, Intensity-Modulated
/
Glottis
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Journal:
Radiation Oncology Journal
Year:
2019
Type:
Article
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