Elucidation of the pathophysiology of intradialytic muscle cramps: pharmacokinetics applied to translational research
Translational and Clinical Pharmacology
;
: 119-122, 2019.
Article
in English
| WPRIM
| ID: wpr-786684
ABSTRACT
In the conventional concept of translational research, investigations flow from the laboratory bench to the bedside. However, clinical research can also serve as the starting point for subsequent laboratory investigations that then lead back to the bedside. This article chronicles the evolution of a series of studies in which a detailed analysis of pharmacokinetics in hemodialysis patients revealed new physiological insight that, through a systems approach incorporating kinetic, physicochemical, physiologic, and clinical trial results, led to an elucidation of the pathophysiology of intradialytic skeletal muscle cramps. Based on this understanding, a therapeutic path forward is proposed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Renin-Angiotensin System
/
Sympathetic Nervous System
/
Systems Analysis
/
Pharmacokinetics
/
Renal Dialysis
/
Muscle, Skeletal
/
Translational Research, Biomedical
/
Muscle Cramp
Limits:
Humans
Language:
English
Journal:
Translational and Clinical Pharmacology
Year:
2019
Type:
Article
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