Interpretation of the hygiene and microflora hypothesis for allergic diseases through epigenetic epidemiology / 한국역학회지
Epidemiology and Health
;
: 2018006-2018.
Article
in English
| WPRIM
| ID: wpr-786867
ABSTRACT
The hygiene hypothesis (HH) proposed by Strachan in 1989 was expanded to explain the inverse association between the occurrence of allergy disorders and the risk of infectious diseases and parasite infestation. The microflora hypothesis (MH) suggests that gut microbial dysbiosis in early life might trigger hypersensitivity disorders. The sharing concept of both HH and MH is gene-environment interaction, which is also a key concept in epigenetics. The amalgamation of epidemiology and epigenetics has created a scientific discipline termed epigenetic epidemiology. To accomplish an era of gene-environment-wide interaction studies, it is necessary to launch a national human epigenome project.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parasites
/
Hygiene
/
Epidemiology
/
Communicable Diseases
/
Allergy and Immunology
/
Epigenomics
/
Gene-Environment Interaction
/
Hygiene Hypothesis
/
Dysbiosis
/
Gastrointestinal Microbiome
Type of study:
Screening study
Limits:
Humans
Language:
English
Journal:
Epidemiology and Health
Year:
2018
Type:
Article
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