A Single Intraperitoneal Injection of Endotoxin Changes Glial Cells in Rats as Revealed by Positron Emission Tomography Using ¹¹CPK11195 / 대한핵의학회잡지
Korean Journal of Nuclear Medicine
;
: 224-228, 2018.
Article
in English
| WPRIM
| ID: wpr-786988
ABSTRACT
PURPOSE:
Intracranial administration of lipopolysaccharide (LPS) is known to elicit a rapid innate immune response, activate glial cells in the brain, and induce depression-like behavior. However, no study has focused on the changes in glial cells induced by intraperitoneal injection of LPS in vivo.METHODS:
Ten adult male Fischer F344 rats underwent [¹¹C]PK11195 PET before and 2 days after intraperitoneal injection of LPS to evaluate the changes in glial cells. The difference in standardized uptake values (SUV) of [¹¹C]PK11195 between before and after injection was determined.RESULTS:
There was a cluster of brain regions that showed significant reductions in SUV. This cluster included the bilateral striata and bilateral frontal regions, especially the somatosensory areas.CONCLUSIONS:
Changes in activity of glial cells induced by the intraperitoneal injection of LPS were detected in vivo by [¹¹C]PK11195 PET. Intraperitoneal injection of LPS is known to induce depression, and further studies with [¹¹C]PK11195 PET would clarify the relationships between neuroinflammation and depression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rats, Inbred F344
/
Brain
/
Lipopolysaccharides
/
Neuroglia
/
Positron-Emission Tomography
/
Depression
/
Electrons
/
Immunity, Innate
/
Injections, Intraperitoneal
Limits:
Animals
/
Humans
/
Male
Language:
English
Journal:
Korean Journal of Nuclear Medicine
Year:
2018
Type:
Article
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