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Inverse Prognostic Relationships of ¹⁸F-FDG PET/CT Metabolic Parameters in Patients with Distal Bile Duct Cancer Undergoing Curative Surgery / 핵의학분자영상
Nuclear Medicine and Molecular Imaging ; : 334-341, 2018.
Article in English | WPRIM | ID: wpr-787016
ABSTRACT

PURPOSE:

As there were few previous studies with a small number of subjects, the purpose of this was to evaluate the prognostic significance of ¹⁸F-FDG PET/CT in patients with distal bile duct cancer undergoing curative surgery.

METHODS:

The study included 40 patients (M/F = 2416; age 68.0 ± 8.0 years) who underwent preoperative ¹⁸F-FDG PET/CT followed by curative surgical resection. The participant's age, sex, Eastern Cooperative Oncology Group performance-status score, baseline serum CA 19-9 level, stage, pathologic T and N stages, tumor size, tumor grade, tumor growth pattern, R0 resection, and adjuvant therapy were included as clinicopathological variables for predicting overall survival. The PET variables were maximum standardized uptake value (SUV(max)), average SUV (SUV(avg)), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of the tumor. The Kaplan-Meyer method and Cox proportional hazards model were used for the survival analysis.

RESULTS:

A total of 15 of 40 patients (37.5%) died during the follow-up period. In univariate analysis, low SUVmax (≤ 2.7, p = 0.0005) and low SUV(avg) (≤ 2.6, p = 0.0034) were significant predictors of poor overall survival. In multivariate analyses, only low SUV(max) (HR = 6.7016, 95% CI 1.9961–22.4993, p = 0.0047) was an independent prognostic factor associated with poor overall survival.

CONCLUSION:

The SUVmax of the primary tumor measured by ¹⁸F-FDG PET/CT was an independent significant prognostic factor for overall survival in patients with distal bile duct cancer. However, different results from a previous study warrant further large sample-sized study.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Bile / Bile Duct Neoplasms / Bile Ducts / Proportional Hazards Models / Multivariate Analysis / Follow-Up Studies / Cholangiocarcinoma / Tumor Burden / Positron Emission Tomography Computed Tomography Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Nuclear Medicine and Molecular Imaging Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Bile / Bile Duct Neoplasms / Bile Ducts / Proportional Hazards Models / Multivariate Analysis / Follow-Up Studies / Cholangiocarcinoma / Tumor Burden / Positron Emission Tomography Computed Tomography Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Nuclear Medicine and Molecular Imaging Year: 2018 Type: Article