Sodium Iodide Symporter (NIS) in the Management of Patients with Thyroid Carcinoma / 핵의학분자영상
Nuclear Medicine and Molecular Imaging
;
: 325-326, 2018.
Article
in English
| WPRIM
| ID: wpr-787018
ABSTRACT
Although radioiodine has been applied in thyroid diseases including carcinoma for over 70 years, it was only in 1996 that the basic molecular mechanism of iodine uptake was identified. Iodide is actively transported into the thyroid via a membrane glycoprotein known as sodium iodide symporter (NIS). NIS mediates radioiodine uptake into thyroid normal and cancer cells. The knowledge on NIS expression has provided scientific background to the empirical management of thyroid carcinoma. Based on recent studies of the NIS gene, this paper provides current clinical applications and future studies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sodium
/
Sodium Iodide
/
Thyroid Diseases
/
Thyroid Gland
/
Thyroid Neoplasms
/
Membrane Glycoproteins
/
Genetic Therapy
/
Ion Transport
/
Theranostic Nanomedicine
/
Iodine
Limits:
Humans
Language:
English
Journal:
Nuclear Medicine and Molecular Imaging
Year:
2018
Type:
Article
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