Novel non-apoptotic cell death: ferroptosis / 영남의대학술지
Yeungnam University Journal of Medicine
;
: 174-181, 2017.
Article
in Korean
| WPRIM
| ID: wpr-787076
ABSTRACT
Ferroptosis is a newly recognized type of cell death that results from iron-dependent lipid peroxidation and is different from other types of cell death, such as apoptosis, necrosis, and autophagic cell death. This type of cell death is characterized by mitochondrial shrinkage with an increased mitochondrial membrane density and outer mitochondrial membrane rupture. Ferroptosis can be induced by a loss of activity of system Xc− and the inhibition of glutathione peroxidase 4, followed by the accumulation of lipid reactive oxygen species (ROS). In addition, inactivation of the mevalonate and transsulfuration pathways is involved in the induction of ferroptosis. Moreover, nicotinamide adenine dinucleotide phosphate oxidase and p53 promote ferroptosis by increasing ROS production, while heat shock protein beta-1 and nuclear factor erythroid 2-related factor 2 inhibit ferroptosis by reducing iron uptake. This article outlines the molecular mechanisms and signaling pathways of ferroptosis regulation, and explains the roles of ferroptosis in human disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxidoreductases
/
Rupture
/
Autophagy
/
Lipid Peroxidation
/
Cell Death
/
Reactive Oxygen Species
/
Apoptosis
/
Mitochondrial Membranes
/
HSP27 Heat-Shock Proteins
/
Glutathione Peroxidase
Limits:
Humans
Language:
Korean
Journal:
Yeungnam University Journal of Medicine
Year:
2017
Type:
Article
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