Nodular Gastritis as a Precursor Lesion of Atrophic and Metaplastic Gastritis / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 332-340, 2019.
Article
in Korean
| WPRIM
| ID: wpr-787163
ABSTRACT
BACKGROUND/AIMS:
Chronic atrophic gastritis (CAG) and metaplastic gastritis (MG) are precancerous conditions of Helicobacter pylori (H. pylori)-related gastric cancer. This study aimed to identify the characteristics of nodular gastritis (NG) showing CAG or MG after nodule regression.METHODS:
H. pylori-infected patients with NG were included after upper gastrointestinal endoscopy. Patients were excluded if their latest endoscopy had been performed ≤36 months after the initial diagnosis of NG. Small-granular-type NG was defined as the condition with 1–2 mm regular subepithelial nodules. Large-nodular-type NG was defined as those with 3–4 mm, irregular subepithelial nodules. The endoscopic findings after nodule regression were recorded.RESULTS:
Among the 97 H. pylori-infected patients with NG, 61 showed nodule regression after a mean follow-up of 73.0±22.0 months. After nodule regression, 16 patients showed a salt-and-pepper appearance and/or transparent submucosal vessels, indicating CAG. Twenty-nine patients showed diffuse irregular elevations and/or whitish plaques, indicating MG. Sixteen patients with other endoscopic findings (14 normal, one erosive gastritis, and one chronic superficial gastritis) showed a higher proportion of H. pylori eradication (12/16, 75.0%) than those in the CAG group (5/16, 31.3%) and MG group (6/29, 20.7%; p=0.001). Patients with small-granular-type NG tended to progress toward CAG (14/27, 51.9%), whereas those with large-nodular-type NG tended to progress toward MG (25/34, 73.5%; p<0.001).CONCLUSIONS:
In patients with a persistent H. pylori infection, NG tended to progress to CAG or MG when the nodules regressed. Small-granular-type NG tended to progress to CAG, whereas large-nodular-type NG tended to progress to MG.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Precancerous Conditions
/
Atrophy
/
Stomach Neoplasms
/
Follow-Up Studies
/
Endoscopy, Gastrointestinal
/
Helicobacter pylori
/
Diagnosis
/
Endoscopy
/
Gastritis
/
Gastritis, Atrophic
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
The Korean Journal of Gastroenterology
Year:
2019
Type:
Article
Similar
MEDLINE
...
LILACS
LIS