Role of Gut Microbiota in Type 2 Diabetes Mellitus and Its Complications: Novel Insights and Potential Intervention Strategies / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 314-320, 2019.
Article
in English
| WPRIM
| ID: wpr-787227
ABSTRACT
Type 2 diabetes mellitus has become one of the fastest growing public health problems worldwide. The disease is believed to involve a complex process involving genetic susceptibility and environmental factors. The human intestine harbors hundreds of trillions of bacteria, as well as bacteriophage particles, viruses, fungi, and archaea, which constitute a complex and dynamic ecosystem referred to as the gut microbiota. Increasing evidence has indicated changes in the gut microbiota composition or function in type 2 diabetic patients. An analysis of ‘dysbiosis’ enables the detection of alterations in the specific bacteria, clusters of bacteria, or bacterial functions associated with the occurrence of type 2 diabetes. These bacteria are involved predominantly in the control of inflammation and energy homeostasis. This review attempts to show that the gut microbiota are important factors for the occurrence of type 2 diabetes and are important for the treatment of gut microbiota dysbiosis through bariatric surgery, fecal microbiota transplantation, prebiotics, and probiotics.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bacteria
/
Bacteriophages
/
Virion
/
Public Health
/
Archaea
/
Ecosystem
/
Probiotics
/
Genetic Predisposition to Disease
/
Diabetes Mellitus, Type 2
/
Bariatric Surgery
Limits:
Humans
Language:
English
Journal:
The Korean Journal of Gastroenterology
Year:
2019
Type:
Article
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