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Differential Activation of Macrophages Based on Their Environment in Advanced Age / 전남의대학술지
Chonnam Medical Journal ; : 12-19, 2020.
Article in English | WPRIM | ID: wpr-787279
ABSTRACT
The macrophage displays functional and phenotypic diversity, which appears, in no small part, to stem from the ability of macrophages to adapt functionally to changes in their tissue microenvironment. Here, we describe the differential activity of peritoneal macrophages with or without the presence of thioglycollate (TG), an inflammatory drug that encouraged the recruitment of macrophages, during aging. The peritoneal-resident macrophages dramatically reduced in phagocytosis and pro-inflammatory cytokines secretion with aging, whereas the functions of macrophages recruited by TG were not significantly changed with aging. These results suggest that macrophages may be changed by their environment in advanced age, and could provide possible explanations for the controversial results regarding differential changes in macrophages in other papers.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Phagocytosis / Aging / Cytokines / Macrophages, Peritoneal / Inflammation / Macrophages Language: English Journal: Chonnam Medical Journal Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phagocytosis / Aging / Cytokines / Macrophages, Peritoneal / Inflammation / Macrophages Language: English Journal: Chonnam Medical Journal Year: 2020 Type: Article