Roles of Sonic Hedgehog Signaling During Tooth Root and Periodontium Formation / 대한소아치과학회지
Journal of Korean Academy of Pediatric Dentistry
;
(4): 144-153, 2018.
Article
in Korean
| WPRIM
| ID: wpr-787316
ABSTRACT
The aim of this study was to understand the roles of Sonic Hedgehog (SHH) signaling during tooth root and periodontium formation. In this study, we generated the dental mesenchyme-specific Smoothened (Smo) activated/inactivated mice with the activity of Cre recombinase under the control of osteocalcin promoter.In the Smo activated mutant molar sections at the postnatal 28 days, we found extremely thin root dentin and widened pulp chamber. Picrosirius red staining showed loosely arranged fibers in the periodontal space and decreased cellular cementum with some root resorption. Immunohistochemical staining showed less localization of matrix proteins such as Bsp, Dmp1, Pstn, and Ank in the cementum, periodontal ligament, and/or cementoblast.In the Smo inactivated mutant mouse, there was not any remarkable differences in the localization of these matrix proteins compared with the wild type. These findings suggest that adequate suppressing regulation of SHH signaling is required in the development of tooth root and periodontium.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Periodontal Ligament
/
Root Resorption
/
Tooth
/
Tooth Root
/
Periodontium
/
Osteocalcin
/
Dental Cementum
/
Dental Pulp Cavity
/
Dentin
/
Recombinases
Limits:
Animals
Language:
Korean
Journal:
Journal of Korean Academy of Pediatric Dentistry
Year:
2018
Type:
Article
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