Effect of Testosterone Replacement Therapy on Cognitive Performance and Depression in Men with Testosterone Deficiency Syndrome
The World Journal of Men's Health
;
: 194-199, 2016.
Article
in English
| WPRIM
| ID: wpr-78766
ABSTRACT
PURPOSE:
We aimed to evaluate the effect of testosterone replacement therapy (TRT) on cognitive function and depression in men with testosterone deficiency syndrome. MATERIALS ANDMETHODS:
We carried out a prospective, placebo-controlled trial involving 106 men with total testosterone levels 0.05). At baseline, no significant differences between the TRT and control groups were noted regarding serum testosterone or prostate-specific antigen levels, or regarding the scores for aging symptoms (Aging Males' Symptoms scale), erectile function (5-item International Index of Erectile Function questionnaire), cognitive function (Korean Mini-Mental State Examination), and depression (Beck Depression Inventory). At 8 months after intervention total serum testosterone levels and erectile function scores had significantly increased (p<0.05), whereas the scores for aging symptoms and depression had significantly decreased (p<0.05) in the TRT group; no significant improvement in any parameters was noted for the control group. Notably, significant improvement in cognitive function was noted among patients with cognitive impairment at baseline (cognitive function score <25) who received TRT.CONCLUSIONS:
TRT may be considered in men with testosterone deficiency syndrome if low testosterone levels are associated with depression or cognitive impairment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Testosterone
/
Aging
/
Prospective Studies
/
Prostate-Specific Antigen
/
Cognition
/
Cognition Disorders
/
Depression
/
Hypogonadism
Type of study:
Controlled clinical trial
/
Observational study
/
Risk factors
Limits:
Humans
/
Male
Language:
English
Journal:
The World Journal of Men's Health
Year:
2016
Type:
Article
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