Serine/arginine-rich splicing factors 2 (SRSF2) and SRSF4 expression patterns in Korean with colon cancer
Korean Journal of Clinical Oncology
;
(2): 115-118, 2016.
Article
in Korean
| WPRIM
| ID: wpr-787988
ABSTRACT
PURPOSE:
Splicing factors play important roles in tumorigenesis. Serine/arginine-rich splicing factors 2 (SRSF2) and SRSF4 proteins, the members of SR family proteins, are dysregulated in various cancers. However, their protein expression levels and diagnostic values are unclear in colorectal cancer.METHODS:
We quantified the protein levels of SRSF2, SRSF4, and previously known colon cancer markers (heterogeneous nuclear ribonucleoprotein A1 [HNRNPA1] and carcinoembryonic antigen [CEA]) in tumor compared with adjacent normal-looking areas (non-tumor) of the colon in Korean patients with colon cancer using immunoblot analysis.RESULTS:
The protein levels of HNRNPA1 and CEA were remarkably increased in tumor compared to non-tumor tissue and up-regulated in all of the tumor samples. However, the protein levels of SRSF2 and SRSF4 in tumor tissue were reduced in contrast with those of non-tumor tissue.CONCLUSION:
None of the SRSF proteins were significantly different between the low (≤II) and high (>II) stages.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ribonucleoproteins
/
Colorectal Neoplasms
/
Carcinoembryonic Antigen
/
Colon
/
Colonic Neoplasms
/
Carcinogenesis
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Clinical Oncology
Year:
2016
Type:
Article
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