Carcinoembryonic antigen levels of tumor-draining venous blood as a prognostic marker in colon cancer
Korean Journal of Clinical Oncology
;
(2): 68-74, 2017.
Article
in English
| WPRIM
| ID: wpr-788018
ABSTRACT
PURPOSE:
Carcinoembryonic antigen (CEA) is a tumor marker for colorectal cancer (CRC) related to recurrence and prognosis. We examined the ability of the CEA level measured directly from a tumor drainage vein (dCEA) to predict the prognosis of CRC more accurately than those from a peripheral vein (pCEA).METHODS:
Fifty-two patients who received curative resection for colon adenocarcinoma were enrolled. The patients were categorized into two groups according to normal pCEA ( < 5.9425 ng/mL, n=24) or elevated pCEA levels (≥5.9425 ng/mL, n=28). Blood was sampled at the time of surgery simultaneously from the tumor drainage vein and from the peripheral vein.RESULTS:
The clinicopathologic variables showed no significant difference between the two groups. Patients with dCEA levels < 20.192 ng/mL showed better disease-free (P=0.009) and overall survival (P=0.033) curves than those with dCEA levels ≥20.192 ng/mL. Elevated dCEA levels were a significant prognostic factor for overall survival and disease-free survival in Cox proportional hazard model analysis (hazard ratio [HR]=399; 95% confidence interval [CI], 16.4–9,747; P < 0.001; HR=9.39, 95% CI, 1.29–68.006; P=0.026). In subgroup analysis, we compared the data of normal range of dCEA group and elevated dCEA group with normal pCEA; the overall survival rate of patients with normal dCEA was better and the disease-free survival rate was significantly better (P=0.003).CONCLUSION:
CEA levels from a tumor drainage vein can be used as more accurate prognostic markers than levels from a peripheral vein in patients with colon cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Recurrence
/
Reference Values
/
Veins
/
Colorectal Neoplasms
/
Adenocarcinoma
/
Carcinoembryonic Antigen
/
Proportional Hazards Models
/
Drainage
/
Survival Rate
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Korean Journal of Clinical Oncology
Year:
2017
Type:
Article
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