The efficacy of chemotherapy in the patients with stage II colon cancer associated with number of high-risk factors
Korean Journal of Clinical Oncology
;
(2): 116-119, 2018.
Article
in English
| WPRIM
| ID: wpr-788036
ABSTRACT
PURPOSE:
This study assessed the effect of chemotherapy over stage II colon cancer in terms of presence of high-risk factors.METHODS:
Data were retrospectively reviewed for 364 patients with stage II colon cancer who underwent curative surgery between January 2007 and December 2012. High-risk factors of stage II colon cancer were examined, and the overall survival (OS) rates were analyzed. Survival benefit of adjuvant chemotherapy was also analyzed.RESULTS:
One hundred and fifteen cases had exclusively single high-risk factor and 194 cases were negative for high-risk factors. Postoperative chemotherapy was performed in 262 of 364 patients (72.0%). The 5-year OS was 79.4% and 86.6% for patients without adjuvant chemotherapy and those with chemotherapy, respectively. The 5-year OS was 88.2% and 83.3% for patients having exclusively single high-risk factor with adjuvant chemotherapy and those without chemotherapy, respectively.CONCLUSION:
Adjuvant chemotherapy for patients with stage II colon cancer having exclusively single high-risk factor could be omitted, weighing up the survival benefit and side effect of chemotherapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Colorectal Neoplasms
/
Survival Analysis
/
Retrospective Studies
/
Chemotherapy, Adjuvant
/
Colon
/
Colonic Neoplasms
/
Drug Therapy
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Korean Journal of Clinical Oncology
Year:
2018
Type:
Article
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