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Predictive Efficacy of Interim Positron Emission Tomography/Computed Tomography (PET/CT) for the Treatment of Aggressive Lymphoma / 전남의대학술지
Chonnam Medical Journal ; : 109-114, 2015.
Article in English | WPRIM | ID: wpr-788322
ABSTRACT
The prognostic value of whole-body positron emission tomography/computed tomography (PET/CT) with 18F-fluoro-2-deoxy-D-glucose (FDG) shortly after the onset of induction chemotherapy or mid treatment could help to predict long-term clinical outcomes in patients with Hodgkin's or Non-Hodgkin's lymphoma. However, FDG is not a tumor-specific substance, and it may accumulate to the point of being detected in a variety of benign conditions or at physiologic anatomical sites, which may give rise to false-positive interpretation. In an attempt to standardize the reporting criteria for interim PET/CT, the First International Workshop on Interim PET in Lymphoma suggested visual response criteria with the Deauville five-point scale, and the standardized uptake value (SUV) has been investigated in comparison with this visual system. A quantitative approach using the measurement of maximal SUV (SUVmax) or the reduction rate of SUVmax (DeltaSUVmax) might be more appropriate in early-response PET/CT for reducing false-positive rates or for decreasing interobserver variability in interpretation. In this review, the predictive efficacy of PET/CT is discussed for the treatment of aggressive lymphoma, especially in terms of an interim PET/CT-based prognostic model.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Lymphoma, Non-Hodgkin / Observer Variation / Positron-Emission Tomography / Education / Electrons / Induction Chemotherapy / Positron Emission Tomography Computed Tomography / Lymphoma Type of study: Prognostic study Limits: Humans Language: English Journal: Chonnam Medical Journal Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Lymphoma, Non-Hodgkin / Observer Variation / Positron-Emission Tomography / Education / Electrons / Induction Chemotherapy / Positron Emission Tomography Computed Tomography / Lymphoma Type of study: Prognostic study Limits: Humans Language: English Journal: Chonnam Medical Journal Year: 2015 Type: Article