Signaling Pathways in Osteoclast Differentiation / 전남의대학술지
Chonnam Medical Journal
;
: 12-17, 2016.
Article
in English
| WPRIM
| ID: wpr-788330
ABSTRACT
Osteoclasts are multinucleated cells of hematopoietic origin that are responsible for the degradation of old bone matrix. Osteoclast differentiation and activity are controlled by two essential cytokines, macrophage colony-stimulating factor (M-CSF) and the receptor activator of nuclear factor-kappaB ligand (RANKL). M-CSF and RANKL bind to their respective receptors c-Fms and RANK to stimulate osteoclast differentiation through regulation of delicate signaling systems. Here, we summarize the critical or essential signaling pathways for osteoclast differentiation including M-CSF-c-Fms signaling, RANKL-RANK signaling, and costimulatory signaling for RANK.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoclasts
/
Bone and Bones
/
Bone Matrix
/
Signal Transduction
/
Cytokines
/
Macrophage Colony-Stimulating Factor
/
RANK Ligand
Language:
English
Journal:
Chonnam Medical Journal
Year:
2016
Type:
Article
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