Factors Associated with C-peptide Levels after Diagnosis in Children with Type 1 Diabetes Mellitus / 전남의대학술지
Chonnam Medical Journal
;
: 216-222, 2017.
Article
in English
| WPRIM
| ID: wpr-788386
ABSTRACT
C-peptide is the best indicator of endogenous insulin secretion in patients with diabetes. This study investigated the relationship between C-peptide levels and clinical/laboratory parameters of children with type 1 diabetes mellitus (T1DM), as measured at 6-month intervals after diagnosis. We retrospectively reviewed the data of 34 children with newly diagnosed T1DM. The study subjects were subdivided into a rapid progression group with C-peptide levels <0.6 ng/mL at 36 months (n=27; Group A) and a slow progression group with C-peptide levels >0.6 ng/mL at 36 months (n=7; Group B). Patients in Group A had a younger mean age at diagnosis (A 9±4.3 years vs. B 13.6±3.6 years; p=0.013) and lower body mass index (BMI) (A 15.5±2.5 kg/m² vs. B 18.7±3.3 kg/m²; p=0.035). There were fewer asymptomatic patients with glucosuria in Group A, with these patients showing more severe symptoms, such as diabetic ketoacidosis (p=0.035), than those in Group B. Group A also had lower initial C-peptide levels (A 0.5±0.46 ng/mL vs. B 1.87±1.08 ng/mL; p=0.001). There were no significant intergroup differences in sex, family history, baseline hemoglobin A1c (HbA1c), potential of hydrogen (pH), autoantibodies or serum insulin. Simple correlation analyses showed that C-peptide levels were correlated with age and BMI, but not with pH, insulin, or HbA1c. Younger patients, who had a lower BMI, significant symptoms with complications, and/or a low initial C-peptide level, tended to show a rapid rate of decrease in C-peptide levels. Early intensive insulin therapy to preserve beta-cell function should be considered in these groups.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autoantibodies
/
C-Peptide
/
Body Mass Index
/
Retrospective Studies
/
Diabetic Ketoacidosis
/
Diabetes Mellitus, Type 1
/
Diagnosis
/
Hydrogen
/
Hydrogen-Ion Concentration
/
Insulin
Type of study:
Diagnostic study
/
Observational study
Limits:
Child
/
Humans
Language:
English
Journal:
Chonnam Medical Journal
Year:
2017
Type:
Article
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