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Role of Recepteur D'origine Nantais on Gastric Cancer Development and Progression / 전남의대학술지
Chonnam Medical Journal ; : 178-186, 2017.
Article in English | WPRIM | ID: wpr-788391
ABSTRACT
Recepteur d'origine nantais (RON) is a receptor tyrosine kinase belonging to the subfamily of which c-MET is the prototype. Large epidemiologic studies have confirmed the strong association between RON and gastric cancer development. Constitutive activation of RON signaling directly correlates with tumorigenic phenotypes of gastric cancer and a poor survival rate in advanced gastric cancer patients. In this review, we focus on recent evidence of the aberrant expression and activation of RON in gastric cancer tumors and provide insights into the mechanism of RON signaling associated with gastric cancer progression and metastasis. Current therapeutics against RON in gastric cancer are summarized.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phenotype / Stomach Neoplasms / Protein-Tyrosine Kinases / Epidemiologic Studies / Survival Rate / Proto-Oncogene Proteins c-met / Neoplasm Metastasis Type of study: Observational study Limits: Humans Language: English Journal: Chonnam Medical Journal Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phenotype / Stomach Neoplasms / Protein-Tyrosine Kinases / Epidemiologic Studies / Survival Rate / Proto-Oncogene Proteins c-met / Neoplasm Metastasis Type of study: Observational study Limits: Humans Language: English Journal: Chonnam Medical Journal Year: 2017 Type: Article