Neonatal Hepatic Hemangioendothelioma: A Single Institute Experience / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
;
: 46-52, 2016.
Article
in Korean
| WPRIM
| ID: wpr-788567
ABSTRACT
BACKGROUND:
Hepatic hemagioendothelioma in neonatal period was rarely seen, so standard treatment does not established yet.METHODS:
A retrospective analysis of patients with neonatal hepatic hemangioendothelioma at Ajou University Hospital between 2001 and 2016 was performed.RESULTS:
Six patients with hepatic hemangioendothelioma in neonatal period were founded. Mean age at diagnosis was 6.1 days (range, 1-26 days). Three patients have no symptoms; diagnostic approach was prenatal ultrasonography in 2 patients, and incidental abnormal ultrasonographic findings in 1 patient, but the other 3 patients have hepatomegaly and/or congestive heart failure. Three patients were observed without treatment and the other 3 patients received medical and/or surgical treatment. Three patients of those who did not receive treatment became spontaneous regression. Of the other 3 patients, 1 patient achieved complete tumor disappearance after surgical resection, another 1 patient achieved to decrease tumor size with interferon-alpha treatment for 6 months and then had complete resolution of tumor after partial liver lobectomy, and other 1 patient who received hepatic artery embolization decreased in the size and number of lesions and then regressed gradually.CONCLUSION:
Asymptomatic patients with neonatal hepatic hemangioendothelioma could have spontaneous remission, but patients with symptoms such as hepatomegaly with congestive heart failure or thrombocytopenia needed to be applied with medical and/or surgical treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Remission, Spontaneous
/
Thrombocytopenia
/
Retrospective Studies
/
Ultrasonography, Prenatal
/
Interferon-alpha
/
Diagnosis
/
Heart Failure
/
Hemangioendothelioma
/
Hepatic Artery
/
Hepatomegaly
Type of study:
Diagnostic study
/
Observational study
Limits:
Humans
Language:
Korean
Journal:
Clinical Pediatric Hematology-Oncology
Year:
2016
Type:
Article
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