Autoimmune Hemolytic Anemia after Intravenous Immunoglobulin Therapy in a Child with Kawasaki Disease / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
;
: 162-166, 2016.
Article
in English
| WPRIM
| ID: wpr-788580
ABSTRACT
Kawasaki disease (KD) can cause acquired heart disease and systemic vasculitis in children. It is treated with intravenous immunoglobulin (IVIG). A significant complication is development of coronary artery lesions such as dilatations or aneurysms. However, uncommon complications can occur, like autoimmune hemolytic anemia when IVIG is used. We present a case of autoimmune hemolytic anemia associated with KD. Dilatation of right coronary artery was found at echocardiography and he was treated twice with IVIG (2 g/kg) with interval of 48 hours. Laboratory finding showed hemoglobin 7.1 g/dL, hematocrit 20.8%, corrected reticulocyte 5.86%, total bilirubin 0.29 mg/dL, lactate dehydrogenase 425 IU/L, and haptoglobin 5 mg/dL. Normocytic, normochromic anemia with anisopoikilocytosis was found on peripheral blood smear, and direct antiglobulin test was positive. The patient was started on oral prednisolone for 3 weeks, with which all symptoms resolved. We report this rare case, prompting consideration of IVIG associated complications when treating KD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reticulocytes
/
Bilirubin
/
Haptoglobins
/
Immunoglobulins
/
Coombs Test
/
Prednisolone
/
Echocardiography
/
Immunization, Passive
/
Immunoglobulins, Intravenous
/
Coronary Vessels
Limits:
Child
/
Humans
Language:
English
Journal:
Clinical Pediatric Hematology-Oncology
Year:
2016
Type:
Article
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