A Case of Pediatric Precursor B-cell Acute Lymphoblastic Leukemia Associated with Translocations (14;18)(q32;q21) and (8;9)(q24;p13) / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
;
: 148-152, 2017.
Article
in English
| WPRIM
| ID: wpr-788605
ABSTRACT
Precursor B-cell acute lymphoblastic leukemia (ALL), which is the most common subtype of pediatric acute leukemia, generally has a good prognosis. However, the prognosis also depends on the genetic abnormalities of the leukemic blast. Concurrent MYC and IGH/BCL2 translocations have recently been reported as a “double hit” in adult patients, but non-immunoglobulin (non-IG)/MYC translocation has rarely been reported. In this paper, we report a case of pediatric precursor B-cell ALL associated with translocations (14;18)(q32;q21) and (8;9)(q24;p13). The patient was a previously healthy 13-year-old boy. Complete remission was not achieved after first-line four-drug induction chemotherapy; thus, intensive salvage regimen, including high-dose cytarabine and L-asparaginase, were administered, which resulted in morphologic remission. However, his disease relapsed during the second cycle of salvage regimen, and he died of sepsis-induced multiorgan failure.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
/
Leukemia
/
Cytarabine
/
Precursor Cells, B-Lymphoid
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Induction Chemotherapy
Type of study:
Prognostic study
Limits:
Adolescent
/
Adult
/
Humans
/
Male
Language:
English
Journal:
Clinical Pediatric Hematology-Oncology
Year:
2017
Type:
Article
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