Effect of Pharmacotherapy with Paroxetine on Biofeedback Measurement Variables in Panic Disorder Patients / 대한정신약물학회지
Korean Journal of Psychopharmacology
;
: 468-473, 2004.
Article
in Korean
| WPRIM
| ID: wpr-78865
ABSTRACT
OBJECTIVE:
There have been much effort to find reliable indicators predicting treatment response in panic disorder. This study aimed to find the effect of pharmacotherapy on biofeedback measurement variables in panic disorder patients.METHOD:
We recruited 38 panic disorder patients (M25, F13) in the Samsung Medical Center, who were diagnosed by the ADIS-IV (Anxiety Disorder Interview Schedule-IV), and 33 normal control subjects (M21 F12). Panic patients were treated with paroxetine for 3 months. All subjects were assessed on forearm and frontal electromyography (EMG), electrodermal response (EDR), and skin temperature in baseline, stress, recovery phases using the Procomp & Biograph biofeedback instrument. Psychological measures such as Hamilton anxiety rating scale (HAM-A), Hamilton depression rating scale (HAM-D), Beck depression inventory (BDI), Spielberger state-trait anxiety inventory (STAI-S, STAI-T), and Anxiety sensitivity index (ASI) were also assessed. All measurements were performed at the beginning of the study and after 3 months of paroxetine treatment.RESULT:
Panic patients had significantly higher scores on psychological measures such as HAM-A, HAM-D, BDI, STAI-S, STAI-T, and ASI (all p values<0.001) before treatment. After 3months of treatment, panic patients showed significant improvement on baseline EDR (z=-2.824, p=0.005), stress EDR (z=-2.691, p=0.007), and recovery EDR (z=-3.416, p=0.001). They also showed significant improvement on HAM-A, HAM-D, BDI, STAI-S, STAI-T, and ASI (all p values<0.001) after treatment.CONCLUSION:
Electrodermal response, one of the biofeedback measurement variables, was suggested to be the possible indicator predicting treatment response in panic disorder.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Anxiety
/
Panic
/
Skin Temperature
/
Biofeedback, Psychology
/
Panic Disorder
/
Paroxetine
/
Depression
/
Drug Therapy
/
Electromyography
/
Forearm
Type of study:
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Psychopharmacology
Year:
2004
Type:
Article
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