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Epilepsy Surgery in 2019: A Time to Change
Journal of Korean Neurosurgical Society ; : 361-365, 2019.
Article in English | WPRIM | ID: wpr-788771
ABSTRACT
Epilepsy has been known to humankind since antiquity. The surgical treatment of epilepsy began in the early days of neurosurgery and has developed greatly. Many surgical procedures have stood the test of time. However, clinicians treating epilepsy patients are now witnessing a huge tide of change. In 2017, the classification system for seizure and epilepsy types was revised nearly 36 years after the previous scheme was released. The actual difference between these systems may not be large, but there have been many conceptual changes, and clinicians must bid farewell to old terminology. Paradigms in drug discovery are changing, and novel antiseizure drugs have been introduced for clinical use. In particular, drugs that target genetic changes harbor greater therapeutic potential than previous screening-based compounds. The concept of focal epilepsy has been challenged, and now epilepsy is regarded as a network disorder. With this novel concept, stereotactic electroencephalography (SEEG) is becoming increasingly popular for the evaluation of dysfunctioning neuronal networks. Minimally invasive ablative therapies using SEEG electrodes and neuromodulatory therapies such as deep brain stimulation and vagus nerve stimulation are widely applied to remedy dysfunctional epilepsy networks. The use of responsive neurostimulation is currently off-label in children with intractable epilepsy.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Seizures / Classification / Epilepsies, Partial / Deep Brain Stimulation / Electrodes / Electroencephalography / Epilepsy / Vagus Nerve Stimulation / Drug Discovery / Drug Resistant Epilepsy Limits: Child / Humans Language: English Journal: Journal of Korean Neurosurgical Society Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Seizures / Classification / Epilepsies, Partial / Deep Brain Stimulation / Electrodes / Electroencephalography / Epilepsy / Vagus Nerve Stimulation / Drug Discovery / Drug Resistant Epilepsy Limits: Child / Humans Language: English Journal: Journal of Korean Neurosurgical Society Year: 2019 Type: Article