Medial temporal lobe epilepsy with hippocampal sclerosis / 国际儿科学杂志

ABSTRACT

The medial temporal lobe epilepsy with hippocampal sclerosis is one of the most common drug resistant epilepsy,which involves complex neural networks and often requires surgical treatment.Studies have shown that it is related to the history of febrile convulsions,however,the further research is needed.Therefore,it is particularly important to accurately identify hippocampal sclerosis and guide clinical treatment.In this paper,the classification of hippocampal sclerosis was summarized,and the possible mechanism of hippocampal sclerosis was explored in terms of cationic-chloride co-transporters,glutamate and its receptors,and changes in expression of mRNA.The characteristics of magnetic resonance,magnetic resonance spectroscopy and PET of hippocampal sclerosis were listed to provide evidence for early recognition of hippocampal sclerosis.In theory,it provides ideas for further prevention of hippocampal sclerosis and improvement of quality of life in patients with medial temporal lobe epilepsy and hippocampal sclerosis.