Anti-tumor effect and mechanisms of shikonin on gliomas / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 489-491, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-789151
ABSTRACT
Shikonin has anti-tumor activity,and it not only can inhibit the proliferation,migration and infiltration of glioma cells,but also induce necroptosis of glioma cells via promoting the production of reactive oxygen species.Shikonin combined with endoplasmic reticulum stress inhibitors or regulatory tactics of microRNA expression may further enhance its killing effect on gliomas.Shikonin armed by nanoparticles shows increased targetability to gliomas.Shikonin combined with tumor-targeted therapeutic drugs or chemotherapeutic drugs is expected to overcome the drug resistance of glioma cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Oncology
Year:
2019
Type:
Article
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