Research of Jiawei-Xiaoyao powder on the Ghrelin, VIP for the non-erosive reflux disease with stagnation of liver Qi and spleen deficiency type / 国际中医中药杂志

ABSTRACT

Objective To investigate the effect of Jiawei-Xiaoyao powder on the levels of somatotropin and vasoaetive intestinal peptide (VIP) in patients with non-erosive reflux disease (NERD).Methods Seventy patients with liver-stagnation and spleen-deficiency NERD who met the inclusion criteria were divided into two groups according to the random number table,35 in each group.The treatment group was orally administered with Jiawei-Xiaoyao powder,and the control group was given oral omeprazole enteric-coated tablets and domperidone.Both groups were treated for 8 weeks.Plasma somatotropin and VIP levels were measured by ELISA.Results After treatment,plasma somatotropin levels (210.96 ± 16.85 pg/ml vs.195.75 ± 12.62 pg/ml,t=4.274) in the treatment group were significantly higher than that in the control group (P＜0.01),and plasma VIP level (16.12 ± 1.41 pg/ml vs.18.57 ± 2.68 pg/ml,t=4.786) in the treatment group was significantly lower than that in the control group (P＜0.01).Conclusions The Jiawei-Xiaoyao powder could reduce plasma VIP level in NERD patients,increase plasma somatotropin levels of NERD.