Efficacy and safety in different doses of atorvastatin for elderly hyperlipidemia / 上海预防医学

ABSTRACT

To investigate the efficacy and safety in different doses of atorvastatin for elderly hyperlipidemia . [ Methods] A total of 153 elderly patients with hyperlipidemia were included , who were randomly divided into two groups .Group A ( n=79 ) received 10 mg/d atorvastatin , and group B ( n=74) 20 mg/d.Before and after treatment of 2 weeks, 8 weeks, were checked the level of blood lipid , functions of liver and kidney, creatine kinase, creatine kinase isoenzymes. [Results] After treatment, the level of TC (cholesterol) was reduced by 19.6%(A) and 20.0%(B) respectively in the two groups. LDL-C (low density lipoprotein cholesterol ) decreased by 17.4%(A) and 20.1%(B) respectively in the two groups.The level of TC, LDL-C in the two groups showed no difference after treatment (P<0.01).The medicine was not found to cause adverse effect in liver and kidney function and myolysis in the two groups (P>0.05).After taking medicine,The level of uric acid(UA) was decreased in group A (P<0.01). There was no difference in the two groups (P>0.05). [Conclusion] Oral administration of lower do-ses of atorvastatin not only lowers the lipid in elderly patients , but also lowers the blood uric acid .And ad-ministration of lower and higher doses of atorvastatin are both effective and safe for elderly hyperlipidemia .