Investigation on iodine nutrition of pregnant women and thyroid function of newborn in Jiangbei District of Ningbo City / 上海预防医学

ABSTRACT

Objective To investigate and evaluate the iodine nutritional status of pregnant women and thyroid function of new born children in Jiangbei District, and provide the basis for rational iodine supplement. Methods From March 2014 to October 2014,three survey spots ( representing the city,the rural-urban continum,and the countryside) investigated a total of 161 pregnant women, whose urine were tested for urine iodine.Comparative analysis was done on iodine nutritional status in different geographical areas and different pregnancy.Blood of pregnant women and matching neonatal umbilical cord blood were tested for free triiodothyronine (FT3) and free thyroxine (FT4) and thyroid-stimulating hormone (TSH), with analysis on the relationship between the two. Results Median of the 161 pregnant women urine iodine level was 178.67μg/L.Among them,the iodine excess ( urine iodine,>500 mu g/L) accounted for 3.73%(6/161),iodine sufficiency (urinary iodine 250~499 μg/L) 33.54%(54/161),iodine moderacy (urinary iodine 150 ~249 μg/L) 22.36%(36/161),iodine deficiency (urinary iodine <150 μg/L) 40.37%(65/161).Urine iodine levels in pregnant women from three different geographical areas showed no statistical difference.Median urine iodine of pregnant women in third trimester was 148.23 μg/L.FT3 ,FT4 level of 36 neonatal was (2.60 ±0.35) and (13.81 ±1.63) pmol/L respectively,the average serum TSH level was 3.38 mIU/L.Pregnant women urine iodine level paired with FT3 , TSH level of neonatal serum showed no correlation (P>0.05),but were positively correlated in FT4 level (P<0.01). Conclusion Iodine nutritional status in most pregnant women in Jiangbei District is at appropriate levels,but there is still some iodine deficiency found in them.Urine iodine content of pregnant women in third trimester was low;FT4 levels were positively correlated in matched pregnant woman and newborn.In view of this situation,monitoring of the iodine nutritional status in pregnant women and neonatal thyroid function should be enhanced.