The cliniacl observation on the influence of combined u se of allopurinol and warfarin on the INR of chronic permanent AF hyperuricemia patients / 上海预防医学

ABSTRACT

Absrtact Object vie To observe the INR of AF hyperuricemia patients 'prothrombin time under the situation where both allopurinol and warfarin are used to the treatment of anticoagulation . Methods A total of 240 patients with chronic permanent AF hyperuricemia were collected and then divided randomly into two groupswarfarin treatment group(120 cases), to maintain the original dose warfarin therapy and keep a low-purine diet;and the combined treatment group (120 cases), also in the conventional warfarin antithrombotic therapy and a low-purine diet, on this basis, plus allopurinol 100 mg, three times a day, which last for two weeks .Then observing and examining the change of the two group's INR after the treat-ment. Results The INR of the combined treatment group was obviously higher than the warfarin group ( P<0 .05 ) . Conclusion Allopurinol can increase antithrombotic effect of warfarin .INR should be monitored regularly during the treatment so as to adjust warfarin dosage accordingly .