Correlation between serum vitamin D level and cardiac diastolic function in patients with essential hy‐ pertension／ / 心血管康复医学杂志

ABSTRACT

Objective:To explore correlation between serum vitamin D level and cardiac diastolic function in patients with essential hypertension (EH) and normal left ventricular systolic function .Methods:A total of 177 EH patients with normal left ventricular systolic function in our department were divided into vitamin D no deficiency group (≥20ng／ml ,n＝62) and vitamin D deficiency group (＜20ng／ml ,n＝115) ,according to serum vitamin D level .The relationship between serum vitamin D level and cardiac diastolic function was analyzed .Results:(1) Compared with vitamin D no deficiency group , there were significant reductions in blood calcium level [ (2.38 ± 0.12) mmol／L vs.(2.32 ± 0.15) mmol／L] ,mitral early diastolic peak flow velocity [E ,(0.73 ± 0.15) m／s vs.(0.66 ± 0.14) m／s] ,ratio of E to late diastolic peak flow velocity (A) [E／A ,(0.86 ± 0.26) vs.(0.76 ± 0.20)] in vitamin D deficiency group , P＜0.05 or ＜0.01 ;(2) Among the total 177 patients ,serum vitamin D level was significant positively correlated with E and E／A ( r＝0.200 ,0.193 , P＝0.008 , 0.01) ;according to age stratification ,serum vitamin D level was significant positively correlated with E and E／A in ≥60 years patients (r＝0.175 ,0.223 ,P＝0.037 ,0.007) ;according to gender stratification ,serum vitamin D level was signifi‐cant positively correlated with E and E／A in male patients ( r＝0.268 ,0.221 , P＝0.003 ,0.014) ;(3) After correcting age and gender ,Logistic regression analysis indicated that serum vitamin D level was significant positively correlated with E and E／A (β＝3.418 ,1.738 , P＝0.002 ,0.023).Conclusion:Serum vitamin D level is significant positively correlated with cardiac diastolic function in EH patients with normal left ventricular systolic function .