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Changes of plasma BNP and copeptin levels in patients with CHF of different degrees and their correla‐tion with cardiac function class / 心血管康复医学杂志
Chinese Journal of cardiovascular Rehabilitation Medicine ; (6): 583-586, 2019.
Article in Chinese | WPRIM | ID: wpr-790134
ABSTRACT

Objective:

To explore changes of plasma levels of BNP and copeptin (CPT) in patients with chronic heart failure (CHF) of different degrees and their correlation with cardiac function class .

Methods:

A total of 150 CHF patients treated in our hospital from Feb 2015 to Feb 2017 ,were selected as CHF group .Another 45 healthy volun‐ teers undergoing physical examination in our hospital simultaneously were regarded as healthy control group .Plasma BNP and CPT levels were compared between two groups .According to NYHA cardiac function class ,CHF group was further divided into class II group (n=48) ,class III group (n=51) and class IV group (n=51).Plasma levels of BNP and CPT etc .were measured and compared among three subgroups .Correlation among BNP ,CPT levels and cardiac function class were analyzed in CHF patients .

Results:

Compared with healthy control group ,there were significant rise in plasma levels of BNP and CPT in CHF group , P= 0.001 both .Compared with class II group , there were significant rise in plasma levels of BNP [ (1002.82 ± 101.33) pmol/L vs.(1515.05 ± 166.73) pmol/L vs.(2102.36 ± 227.32) pmol/L] ,CPT [ (6.51 ± 1.01 ) pmol/L vs.(9.28 ± 2.89 ) pmol/L vs .(14.03 ± 3.72 ) pmol/L] and LVEDd [ (51.51 ± 4. 01) mm vs.(59.28 ± 6.19) mm vs.(64. 03 ± 5.72) mm] ,and significant reduc‐tion in LVEF [ (50. 82 ± 6. 33)% vs.(45.05 ± 4.73)% vs.(41.36 ± 2.32)%] in class III group and class IV group , and plasma levels of BNP ,CPT ,LVEDd in class IV group were significantly higher than those of class III group , and LVEF was significantly lower than that of class III group , P=0. 001 all.Spearman correlation analysis indicated that plasma levels of BNP and CPT were significant positively correlated with cardiac function class in CHF patients ( r=0.320 ,0.302 , P=0.009 ,0.011).

Conclusion:

Along with CHF aggravates ,the plasma levels of BNP and CPT significantly rise .Cardiac function class is significant positively correlated with plasma levels of BNP and CPT .

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of cardiovascular Rehabilitation Medicine Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of cardiovascular Rehabilitation Medicine Year: 2019 Type: Article